Cell Culture Startup “Integriculture” Utilizes Cultured Meat Technology to Develop World’s First Skin Care Cosmetic Ingredients | TechCrunch Japan

On April 7, cell culture startup Integriculture developed the skin care cosmetic ingredient “CELLAMENT” and set up a mass production system. Announced that it has started business talks.

Cerament uses highly safe eggs (domestic) that are also used in vaccine production as raw materials, and is the world’s first raw material for cosmetics in the culture supernatant of egg-derived “chicken embryo membrane (placenta-like) tissue”. It is said. It is rich in bioactive substances useful for the skin such as growth factors, amino acids, and vitamins, and has confirmed evidence such as promotion of fibroblast growth, antioxidants, moisturizing, and suppression of sebum synthesis.

In the development of cosmetic raw materials, the company aims to realize a diverse and prosperous future by effectively utilizing animal cell resources through a cellular agriculture approach.

Cellular agriculture is a new concept of resource production that can produce exactly the same agricultural products as meat and dairy products by culturing the cells that make up the organism in vitro without raising animals as in the past. Compared to traditional agriculture, it has a smaller environmental impact and is expected to be a sustainable production method.

Cerament overview

  • Cosmetic name: Chicken extraembryonic membrane cell acclimation culture medium
  • Patent application number:2018-210910
  • Country of manufacture:Japan
  • Eight safety tests cleared: Human skin patch test, 3D skin primary irritation alternative test, 3D eye irritation alternative test, skin sensitization alternative test (KeratinoSens, h-CLAT), RIPT test (allergy test / cumulative stimulation), allergen analysis, virus Examination, chromosomal abnormality
  • Official site:https://www.cellament.jp/

Established in October 2015, Integriculture is a research and development type startup that started from research and development of culture meat making based on cell culture technology. We are developing our business centered on our proprietary low-cost, general-purpose large-scale cell culture technology “CulNet System”.

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According to the company, in the research and development of cultured meat, the cells that make up the “co-culture” that cultures two or more cell types and tissues together in the CulNet System produce ingredients that are useful for the skin. It is said that he found it. After conducting research for about two years to apply it to cosmetic applications, we developed and commercialized the culture supernatant of three types of cells (3mix cells) in the placenta-like tissue of eggs as a new cosmetic raw material “Cerament”. The 3mix cells are the three cells in the embryonic membrane (the part corresponding to the placenta) of chicken eggs: “amniotic membrane” (good), “yolk sac” (ranou), and “serosal membrane” (serosal membrane). It is a collection of allantois).

When the collected cells are cultured, a large amount of growth factor is secreted from the cells in the culture medium. The supernatant from which cells have been removed is called the culture supernatant.It is said that this culture supernatant contains abundant signal transmitters that are the key to cell activity.

Cerament has been registered as a new cosmetic ingredient by the PCPC (Personal Care Products Council), and is the world’s first cosmetic ingredient for culture supernatant of egg-derived placental-like tissue.

Integriculture’s CulNet System is a device (patented) that uses the company’s unique general-purpose large-scale cell culture technology (general-purpose cell culture platform) to create an environment that mimics cell-cell interactions in animals.

By constructing an environment that imitates the inside of an animal, it is not necessary to add external growth factors, which was a cause of high cost of cell culture, and a wide range of applications from extract components that can be used for cosmetics to cell components used for meat. It is said that the ingredients with the above can be mass-produced at low cost. Theoretically, all animal cells can be cultivated on a large scale and at low cost, and it is expected to be used for various purposes.

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Already at the laboratory scale, various cells are automatically cultured under a controlled control device, and the production of serum components, which contributed to the high cost, has been realized (patent pending). By realizing in-house production of serum components, it is not necessary to use fetal bovine serum and growth factors, which are the main causes of high cost of conventional cell culture, and it is said that the cost of cell culture will be significantly reduced.

Related article
・ Higher Steaks unveiled laboratory-grown pork roses and bacon made by cell culture
・ Toyo Seikan Group invested in Shiok Meats, a startup for developing cell-cultured meat of shrimp and crustaceans
・ Integraculture, a cell culture startup, started research and development of shrimp cell culture meat, and teamed up with a Singapore company.
・ Integriculture raises 300 million yen to realize “artificial foie gras” with cell culture technology

Category: Biotech
Tags: integrity culture (company), cell culture (term), cultured meat (term), cosmetology (term), make-up / makeup (term), Japan (country / region)


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