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Engineered enzyme erases a stubborn mark of aging by up to 70% in human tissue samples

An engineered enzyme has demonstrated the ability to reverse a chemical hallmark of aging by up to 70% in human tissue samples.

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The brief

Revel Pharmaceuticals and its collaborators have reported the use of an engineered enzyme to reverse protein chemical aging. This process, described as enzymatic deglycation, targets protein damage that accumulates over time in human tissue.

Coverage from Nature, C&EN, and Phys.org emphasizes the enzyme's efficiency in erasing stubborn marks of aging, with the-scientist.com describing the mechanism as "lawnmower-like." The findings indicate a reversal of molecular aging by up to 70% in the studied samples. Future attention will center on the application of this enzymatic deglycation to tackle protein damage and its effects on human tissue.

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Quick answers

What is the reported effectiveness of the engineered enzyme?

The enzyme erased a chemical mark of aging by up to 70% in human tissue samples.

Who is responsible for the research?

The reports credit Revel Pharmaceuticals and its collaborators.

What specific process is used to reverse aging markers?

The process is identified as enzymatic deglycation.

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